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KMID : 0613820190290101096
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Journal of Life Science
2019 Volume.29 No. 10 p.1096 ~ p.1103
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Inhibitory Effect of Protaetia brevitarsis seulensis Ethanol Extract on Neuroinflammation in LPS-stimulated BV-2 Microglia
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Lee Hwa-Jeong
Seo Min-Chul
Lee Joon-Ha
Kim In-Woo
Kim Sun-Young
Hwang Jae-Sam
Kim Mi-Ae
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Abstract
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Neuroinflammation is mediated by the activation of microglia and has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. Therefore, the inhibition of neuroinflammation may be an effective solution to treat these brain disorders. Protaetia brevitarsis seulensis is an insect belonging to the order Coleoptera and inhabits Korea, China, Japan and Siberia. P. brevitarsis seulensis is an edible insect that can be consumed as a protein source for humans. It has been reported that P. brevitarsis seulensis contains useful bioactive substances for hepatoprotection and improving blood circulation, such as indole alkaloids. Microglia cells are the main source of proinflammatory cytokines and nitric oxide (NO) in the central nervous system, which Perform neuroimmune, inflammatory, and other neurobilogical functions. In this study, we investigated the anti-neuroinflammatory effects of P. brevitarsis seulensis ethanol extract (PBE) in activated microglia cells treated with lipopolysaccgarude (LPS, 100 ng/ml). As a result, PBE significantly inhibited NO production without cytotoxicity and decreased the expression levels of inducible NO synthase and cyclooxygenase-2. In addition, the production of inflammatory cytokine secreted by LPS was also reduced by PBE. These results suggest that PBE could be a good source of functional substances to prevent neuroinflammation and neurodegenerative diseases.
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KEYWORD
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Inflammatory cytokine, microglia, neuroinflammation, nitric oxide, Protaetia brevitarsis seulensis
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